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Martins J, Rodrigues D, Silva K, et al

Genomic duplication and overexpression of TJP2/ZO-2 leads to altered expression of apoptosis genes in progressive nonsyndromic hearing loss DFNA51

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GSEA analysis was performed for each gene signature

The extract displayed dose- and time-dependent antiproliferative effects on A549 cells, with IC 50 decreasing from 340.63 g/mL at 24 h to 107.08 g/mL at 72 h, indicating enhanced cytotoxicity over time