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GPX4 in cell death, autophagy, and disease PMC A single mutation in the GPX4 enzyme disrupts a critical membrane anchoring loop, triggering ferroptosis and early onset childhood dementia. New findings reveal ferroptosis as a direct driver of neurodegenerationand point to emerging therapeutic Selective Small Molecule Activator of Patient Derived GPX4 Variant ACS Chemical Biology The Selenoprotein Glutathione Peroxidase 4: From Molecular Mechanisms to Novel Therapeutic Opportunities PMC Glutathione peroxidase 4 (GPX4) Expert tips Abcam GPX4 independent ferroptosisa new strategy in disease's therapy Cell Death Discovery
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