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Nevertheless, supplementation with 2 mg/d folic acid, 25 mg/d vitamin B6, and 400 g/d B12 during 6 months significantly decreased the homocysteine levels, severity, and disability of migraine attacks (60)

2019;98(26):e16163

The combined model output was validated by replicating Figs 2 and 6 from the Reed et al

This increase in plasma lactate is essential for activated T cells and also supports the increased lactate demand by neurons due to increased oxidative stress (200)