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The observed beneficial effect of canagliflozin was associated with a significant reduction of MDA, and enhanced expression of SOD and GSH in the calcified aortas of both canagliflozin-treated groups

However, severely distorted pelvic anatomy increases surgical risk, making assisted reproductive technologies (ART) like IVF preferable in such scenarios ( 3.4 Disruption of folliculogenesis and oocyte function by the endometriotic microenvironment The endometriotic microenvironment is characterized by elevated levels of reactive oxygen species (ROS), iron overload, pro-inflammatory cytokines, and altered immune cell infiltration

These associations were identified in separate analyses of the cases with gestational diabetes mellitus and the controls

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Therefore, testosterone propionate was withdrawn and the less active testosterone undecanoate formulation (20 mg/die) was initiated, aiming to reduce the androgen effect on bone maturation

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