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The newly formed LOO can subsequently abstracts the hydrogen from a second PUFA affords the lipid hydroperoxide (LOOH) [23]

[ 41 ] a-Lipoic acid is also neuroprotective, scavenges nitric oxide and peroxynitrite, and may be especially promising as an antioxidant against mitochondrial dysfunction.40 The supplement coenzyme Q10 has similar neuroprotective qualities and has the ability to improve mitochondrial function

In contrast to wild-type enzyme, the C47S mutation induces a positive cooperativity toward GSNO binding

doi: 10.3390/v15020351 88 MonzelA

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