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Thus, how to protect grafted islets without the long-term use of systemic immunosuppression has become a focused research area (117)

Innovative approaches such as engineering EVs to enhance targeting and therapeutic payload delivery are under investigation to improve efficacy [131-132]

The Real Solution Is Rebuilding Gut Resilience True gut repair doesnt come from avoiding bad foods or relying on expensive powders

Myeloid-mediated immunosuppression and stromal exclusion emerge as key actionable microenvironmental resistance axes, given that are particularly amenable to therapeutic intervention, supported by the clinical availability of VEGF-targeting agents, CSF1R inhibitors, and immunomodulatory combination strategies

Collectively, these mechanisms reveal the dual role of epithelial cells in antiviral defense and inflammatory pathology, providing mechanistic insights into respiratory infectious disease progression and potential therapeutic targets

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