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doi: 10.1016/j.tracli.2022.09.002

5 AxarliI.DhavalaP.PapageorgiouA

Intermediate hyperhomocysteinemia (fasting plasma tHcy 30-100 mol/L) is usually the result of moderate/severe vitamin B12 or folate deficiency, homozygous enzyme defects in homocysteine metabolism, or renal failure.34,57 Again, diagnosis and reversal of the respective cause should be the main priority, while most patients respond well to folate alone or in combination with B12, B6 and possibly betaine

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Lifestyle considerations: While dietary B12 intake is not relevant in pernicious anaemia (due to malabsorption), maintaining a balanced diet supports overall health

Ascorbic Acid, or Vitamin C, can interact with certain medications, including chemotherapy drugs, statins, and warfarin