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Please consult the 2025 Summary of Major Modifications and Explanatory Notes for the full list of modifications

A clinical hierarchy: dont stack until youve earned the right to stack Before we even talk combinations, an evidence-led clinic typically wants these foundations in place: Diagnosis clarity: Obesity phenotype, insulin resistance, prediabetes/T2D, dyslipidemia, sleep apnea risk, NAFLD risk Baseline labs: A1c, fasting glucose/insulin (or at least glucose), lipids, CMP, CBC

For Canadians seeking significant body composition changes, Retatrutide represents the most promising peptide currently in late-stage development, with protein intake of 80-100g daily being essential for optimal muscle preservation during treatment