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Known as Kayser Fleischer rings, an ophthalmologist will diagnose this phenomenon

doi: 10.3233/JAD-160685

There are several possible reasons why vitamin E is ineffective in the treatment of human diseases

In an uncontrolled clinical trial in 23 women with rosacea, use of a topical 0.05% retinaldehyde cream once daily for six months led to modest improvement in rosacea-related facial redness and telangiectasia in 75% of participants

Furthermore, pericyte-derived inflammatory mediators such as IL-6 recruit neutrophils, exacerbating BBB disruption

This underscores a greater need for standardised multidisciplinary definitions, as evidenced by recent consensus papers on definitions, such as for neurological irAEs 8