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However, when ALOX12 was depleted, the expression of p53 and SLC7A11 was not affected [19]

Previous studies have reported that GPX4 regulates neutrophil survival and inflammation by limiting ferroptosis (25) In addition, GPX4, together with vitamin E, protects hematopoietic stem and progenitor cells from lipid peroxidation, thereby maintaining white blood cell homeostasis (34)

Acknowledgements Authors are grateful to Panjab University, Chandigarh, India for facilities

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Upon an ingestion of grape juice, NO production is increased in the serum endothelial cells of preeclampsia patients (115), which is recognized to trigger SIRT1-eNOS-NO axis

The activation of AHR caused the upregulation of GLP-1 and IL-22 at proteins and mRNA levels, decreased systemic LPS, improved gut barrier function, activated the hepatic STAT3/IL-22R/peroxisomal acyl-coenzyme A oxidase 1 (ACOX1) and pancreatic GLP-1R/p-CREB signaling pathways, and improved lipid metabolism and insulin resistance