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In recent years, the incidence of DOR has been steadily increasing

Studies demonstrate that LPS activates adipose tissue macrophages via TLR4 receptors, promoting the release of proinflammatory cytokines such as TNF-, which in turn induces excessive lipolysis in adipocytes, generating large quantities of free fatty acids (FFAs) ( 3.5 Hypothalamic-pituitary-ovarian axis disruption Disruption of gut microbiota leading to systemic LPS translocation not only impairs peripheral organ function but also exacerbates PCOS pathology by interfering with the neuroendocrine regulation of the HPO axis ( 4 Gut microbiota characteristics in PCOS Recent studies have shown distinct differences in gut microbial composition between PCOS and healthy controls

In rodent models, supplementation with butyrate induces the expression of metabolically important genes that can improve insulin sensitivity linked to augmented energy expenditure 67

Oxid Commun 40:301308 Kroniak M, Gsto M, Szakowski M, Zagrodzki P, Derwisz M (2010) Cornelian cherry ( Cornus mas L.) juices as a source of minerals in human diet

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It influences stress-related neurotransmitters like gamma-aminobutyric acid (GABA), promoting calmness and relaxation