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Description

Role in Animal Health & Performance

The first evidence of an anticancer activity attributed to an NAPRT inhibitor was reported by our group in 2017 when we demonstrated that the prototypical NAPRT inhibitor 2-HNA cooperates with FK866 in blunting NAD + levels in the NAPRT-proficient ovarian cancer OVCAR-5 cells

It drives many pathological conditions (Figure 1)

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[PubMed Citation] Diaquacobinamide (H(2)O)(2)Cbi(2+) or its conjugate base hydroxyaquacobinamide (OH(H(2)O)Cbi(+))) can bind up to two cyanide ions, making dicyanocobinamide