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Excessive levels of TGF- can cause immunosuppression and promote fibrosis and cellular proliferation, leading to carcinogenesis [74] fibrotic diseases such as pulmonary fibrosis and systemic sclerosis [75], and infection [76]

proposed that the PFC-Hip-Amy circuit exhibits different activity patterns during various sleep states such as wakefulness (W), Non-Rapid Eye Movement (NREM), and Rapid Eye Movement (REM) sleep

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479 In conclusion, the current goal of improving AIT is to shorten the treatment time, improve its efficiency in order to promote the absorption and presentation of allergens, reduce side effects to improve safety, improve patient compliance, and ultimately significantly increase the utilization of this treatment method