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The rewarding and cognitive effects of nicotine are mediated through the activation of mesocortical DA receptors in the prefrontal cortex and anterior cingulate cortex, while the activation of DA receptors by nicotine in the nucleus accumbens and amygdala modulate synaptic plasticity and long-term potentiation that are more important in addiction

BMC Pulm Med (2014) 14:32

When nicotine hits your brain quickly, it reinforces the connection between the action and the reward, strengthening addictive behaviour

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Compared to non-smokers, smoking increases women's risk of lung cancer by 13 times and men's by 23 times