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Experimental perturbations in central-carbon metabolism that increase the KG/succinate ratio can enhance the activity of KG-dependent dioxygenases and bias embryonic stem (ES) cells and certain models of cancer towards differentiation 1,2,3

This further confirms the association between soybean consumption and a reduced risk of CRC (Wang et al., 2024)

however, MitoQ, as an efficient mtROS scavenger, reduced the generation of mtROS and effectively inhibited the phosphorylation of Drp1, indicating that Drp1 is regulated by mtROS