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TP53 can also enhance multienzyme activity to facilitate the accumulation of ROS

Pancreatic Cancer Pancreatic ductal adenocarcinoma (PDAC) is characterized by a poor 5-year survival rate (~10%) due to inherent chemoresistance, barriers to drug delivery, and a lack of early diagnostics

Further investigation is required to elucidate the specific role of GPX3 in lipid metabolism within OCSCs (115)

Elsevier, 2019

Diabetic complications : Diabetes is associated with glycation of proteins, including enzymes like GR, potentially impairing their function

On account of GBM is characterized by resistance to drug-induced apoptosis, research into the mechanisms and inducers of pyroptosis may contribute to the development of new GBM treatment strategies