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Research shows glutathione depletion becomes measurable above 2,000 mg/day, with greater depletion at 3,0004,000 mg/day and overdose levels

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Toxicol Appl Pharmacol 83:1427 de Quay B, Malinverni R, Lauterburg BH (1992) Glutathione depletion in HIV-infected patients: role of cysteine deficiency and effect of oral N -acetylcysteine

For example, crocetin upregulates autophagy-related genes such as the AMPK/mTOR signaling pathway, thereby promoting cell autophagy, removing damaged organelles and proteins, and enhancing neuronal repair capacity (Guo et al., 2022)

improves the effect of pain-relieving hormones (e.g., cortisone) by facilitating their penetration into the cells (thanks to increased membrane permeability), is said to have a decongestant effect, and promotes blood circulation and nutrient supply to the tissues