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We cultured murine TDP-43 +/+ and TDP-43 K408R/K408R primary cortical neurons and performed stress and recovery assays to determine how the cell stress response may be affected

Formulated as a 2% eyedrop to manage glaucoma and ocular hypertension, dorzolamide shows a 4000-fold greater affinity for carbonic anhydrase II than carbonic anhydrase I [256]

Indian J Exp Biol 1996

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If you're feeling that, it's not a sign of the peptide 'working'it's a signal that something in your process needs to be adjusted