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We quantified the abundance of 18,285 peptides, representing 2,134 proteins, and 7,537 peptides with any of ten different PTMs, including oxidation (M, C), deamidation followed by methylation (N, Q), methylation (K, D, E), phosphorylation (S, T, Y), acetylation (K), irreversible beta elimination of C thiol to dehydroalanine (CysDha), glutathionylation (C), lactylation (K), and dioxidation of C (sulfonic acid or sulfenic acid)

Vascular Dysfunction : Compromise of the blood-brain barrier integrity leads to impaired nutrient and oxygen supply, contributing to neuronal dysfunction