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Plausible signaling is a starting point for investigation, not a substitute for human safety and efficacy data

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When to Stop Some situations call for discontinuation, not just an off-cycle: Active or recently diagnosed malignancy New uncontrolled diabetes New thyroid abnormality Persistent side effects that carry across multiple cycles You've reached your goal and don't need maintenance The boring truth is that the last one applies more often than people admit

Additionally, the RIPK1 S32A mutation significantly inhibited Huh7 cell proliferation following TNF treatment, as demonstrated by colony formation assays (Supplementary Fig