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Mechanistically, PA reduces the expression of GPX4 and heat shock factor 1 and regulates the transcription of genes related to iron metabolism (such as FTH, TFR1, and SLC40A1), causing iron homeostasis imbalance, while GPX4 overexpression reverses PA-induced ferroptosis in cardiomyocytes

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Author Contributions Concept and design: Karthikeyan Ramalingam, Ameena M, Meignana Arumugham I Acquisition, analysis, or interpretation of data: Karthikeyan Ramalingam, Ameena M, Rajeshkumar Shanmugam Drafting of the manuscript: Karthikeyan Ramalingam, Ameena M, Meignana Arumugham I, Rajeshkumar Shanmugam Critical review of the manuscript for important intellectual content: Karthikeyan Ramalingam Supervision: Karthikeyan Ramalingam References 1.Coconut phytocompounds inhibits polyol pathway enzymes: implication in prevention of microvascular diabetic complications

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doi: 10.1016/j.immuni.2019.08.001 [DOI] [PMC free article] [PubMed] [Google Scholar] 127.Hall Jason A, Maria P, Lina K, Bo-Ram K, Yong KS

[60] identified phospholipid-modifying enzymes Lysophospholipid acyltransferase 1 (also known as MBOAT1) and Lysophospholipid acyltransferase 2 (also known as MBOAT2) as ferroptosis suppressors through a whole-genome CRISPR activation screen