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In an SPF facility, diabetes did not develop in NOD mice because of the role of innate signalling in modifying the gut microflora

This feature is attributed to its distinct amino acid composition and spatial arrangement

On the contrary, arginine supplementation significantly alleviates the above problems and increases wound strength

10.1016/j.jaac.2014.01.018 251

Lifestyle interventions ( e.g ., diet and exercise) and pharmacological treatments ( e.g ., metformin, GLP-1 receptor agonists) can ameliorate insulin resistance and improve metabolic outcomes in PCOS (1, 11)