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doi: 10.1016/j.celrep.2017.12.002

Contrary to expectations, BMP genes usually showing opposing effects to Wnt signaling exhibited increases after treatment with Wnt agonist drugs

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3.2 Bidirectional regulation of lipid metabolism Lipid metabolism serves as a critical bidirectional regulator of CD4 + T cell differentiation, dynamically shaping the balance between pro-inflammatory Th17 cells and immunoregulatory Treg cells through integrated control of extracellular lipid uptake, intracellular synthesis, and FAO (90, 91)