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Three millions of people so dead to all the feelings of liberty as voluntarily to submit to be slaves, would have been fit instruments to make slaves of the rest." Alluding to the alleged strength of Great Britain and the weakness of America, he said, "It is true, that in a good cause, on a good ground, the force of this country could crush America to atoms

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Acknowledgements The authors would like to thank members of the Hubrecht Institute Flow Cytometry and Animal facilities for essential support

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Furthermore, in a mouse model of melanoma, the neutralizing effect of bicarbonate increased the efficacy of anti-PD-1 and anti-CTLA4 immunotherapy [377]