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9 Despite its severity, DN has received comparatively less attention in clinical research and therapeutic development than other diabetic complications, such as nephropathy and retinopathy, necessitating further research

GCH1 selectively prevented the consumption of phospholipids containing two polyunsaturated fatty acid acyl tails, and increased BH4/BH2 to inhibit lipid peroxidation and iron ion denaturation (57)