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In these cells, the transcription factor FOXO4 is highly upregulated and physically sequesters the tumor suppressor p53 in nuclear foci, preventing p53 from triggering apoptosis

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10.1016/j.bbrc.2009.09.018 164 TanS

FIGURE 5 5 Experimental models of ovarian oxidative stress Experimental models have been instrumental in elucidating the role of oxidative stress in ovarian dysfunction, enabling the dissection of underlying molecular mechanisms and the assessment of targeted interventions