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Aligning with such neurocognitive observations, structural magnetic resonance imaging (MRI) studies have detected reduced gray matter integrity among smokers in multiple discrete brain regions including the prefrontal cortex (PFC), ACC, insula, thalamus, and cerebellum [e.g., 1417]

Edith Mitchell, a medical oncologist at the Sidney Kimmel Cancer Center in Philadelphia, said that in addition to promoting healthy habits such as quitting smoking and exercising, studies should also focus on genetics, biology, and social and environmental factors

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