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Of note, this pathway of arginine-induced efferocytosis (with arginine derived from engulfed apoptotic cells) is complemented by efferocytosis-induced glycolysis dependent on activation of the enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 (PFKFB2), triggering enhanced binding of apoptotic cells to the macrophage cell surface via glycolysis-derived lactate (Schilperoort et al., 2023)