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A second Lys to Arg substitution at position 34 eliminates a potential competing acylation site, ensuring homogeneous conjugation exclusively at Lys26 and simplifying downstream purification

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A higher-dose oral semaglutide formulation (25 mg and 50 mg) is in development for obesity, but it still carries the same administration constraints

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10.4049/jimmunol.181.7.4461 173 SuciatiA.Maryati, (2023)