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The binding of cinnamic acids such as ferulic acid or caffeic acid was higher compared to the binding of benzoic acids like vanillic acid or gallic acid

Moreover, recruited neutrophils during the inductions inflammatory phase (first week) will further participate in tissue injury and fibrosis by producing matrix-degrading enzymes such as neutrophil elastase and releasing excessive ROS 12

It is a serine protease enzyme that circulates in the blood plasma and is crucial for inflammation and immunity

doi: 10.1007/s12011-021-02613-5 51

Under these conditions, HIFs are activated and promote the expression of various genes that lead to tumor vascularization, epithelialmesenchymal transition (EMT), invasion/metastasis, cancer-specific metabolism, immune escape, and cancer stem cell (CSC) trait acquisition

Competing Interests The authors declare they no competing interests