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doi: 10.1016/j.scitotenv.2013.08.057

By unregulating Notch and p53 signaling pathways and secreting matrix metalloproteinases (MMPs), growth factors, and cytokines, they stimulate angiogenesis, inflammatory response, cell proliferation, and invasion (67, 68)

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(2019), heavy metal treatment has synthesized new polypeptides, which can help increase heavy metal tolerance