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EMA www.ema.europa.eu/en/development-new-medicinal-products-treatment-ulcerative-colitis-scientific-guideline (2019)

Koliada, A

Indeed, chronic hyperglycemia drives intestinal barrier dysregulation by direct action on gene transcription [129]

42 Additionally, liver iron concentration correlates linearly with the total body iron stores, making it a widely accepted surrogate for assessing total iron levels

The baseline selenium status of an individual could constitute the most important parameter modifying the outcome of selenium supplementation, which might primarily disrupt self-amplifying cycles of the endocrineimmune system interface rectifying the interaction of lymphocytes with thyroid autoantigens