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Accordingly, selective targeting of GSH-dependent nodes (such as cysteine transport, mitochondrial GSH import, compartmentalized GSH degradation, or NADPH-dependent regeneration) may offer greater specificity and efficacy than indiscriminate redox perturbation

Rosae Silva JCdoAmara VFMendonaJLRosae Silva ACNakaoLSPoliNeto OBet al

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ROS can induce mutations in the BRCA1 gene, which is involved in DNA repair, leading to impaired DNA damage response and increased susceptibility to tumorigenesis [100]

Furthermore, studies have shown that EGCG can simultaneously prevent neuronal apoptosis induced by TNF and H 2 O 2