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SKU: 30994126094
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Description

However, how this change arises and contributes to HD pathogenesis is unclear

J Biol Chem 265:2043720442 Downward J, Graves JD, Warne PH et al (1990) Stimulation of p21ras upon T-cell activation

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Recent research supports a prion-like propagation model, where pathogenic -synuclein spreads trans-neuronally via exosomes and synaptic transmission, initiating a chain reaction of misfolding across interconnected brain regions

SUMMARY POINTS

376 Arimoclomol, a co-inducer of HSP27 and HSP70, has demonstrated efficacy in ALS and HD models by reducing protein aggregation and improving neuronal survival