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Methods Studies published in peer-reviewed journals were considered for inclusion in the current review

Methylcobalamin and adenosylcobalamin represent the two active forms that participate directly in cellular metabolism

Managing injection site reactions Redness, swelling, or itching at the injection site affects a subset of patients

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First, only two out of the four studies considered vitamin B 12 , methylmalonic acid and homocysteine levels as possible confounders for the response to vitamin B 12 therapy.(10,11) Vitamin B 12 deficiency is known to cause peripheral neuropathy and is a risk factor for development of DPN in diabetics who are on metformin