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In summary, the accumulation of TMAO will not only increase oxidative stress and endothelial cell damage and permeability but also lead to an increase endothelial-derived NOS expression ( Vascular Calcification: TMAO Activates the NLRP3 Inflammasome and NF-B Signaling Pathway in Vascular Smooth Muscle Cells (VSMCs) Vascular calcification (VC) is a phenomenon of disseminated deposition of mineral content within the medial layer of arteries

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(download DOCX Tables S1-S2 and Figures S1-S12 Rights and permissions Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made

Contrarily, the observations of Mosleh et al