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These enzymes include catalase, glutathione peroxidase, and other peroxidases such as cytochrome c peroxidase and NADH peroxidase [2]

Interestingly, GHK alone appeared to produce a comparable stimulatory action, while copper(II) ions in isolation may indicate no such activity, suggesting the tripeptide moiety may be the primary active component, possibly reforming complexes with trace copper present in the culture medium

Bioavailability varies widely depending on the device but can exceed nasal delivery for some formulations

This indicates that stimulating GSH production, which has been shown to prevent degeneration of RPE cells 70 , could potentially serve as an intervention strategy to combat ROS in maturing mouse retinas with RP where all rods have degenerated

10.1038/s41598-018-26296-6 [DOI] [PMC free article] [PubMed] [Google Scholar] Ribas V., Garca-Ruiz C., Fernndez-Checa J