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Other symptoms are also reported, including the development of tumors in rodents [increased tumor necrosis factor (TNF)- secretion

however, antimuscarinics can be administered safely to patients with open-angle glaucoma who are being treated with miotics

Aging further exacerbates vulnerability: in aged or overweight mice, reduced basal NRF2 antioxidant capacity and diminished mitochondrial reserve in aged or overweight mice lead to exaggerated ROS surges and excessive UPR activation during I/R (120), whereas short-term fasting reinduces NRF2, lessens acute necrosis, and mitigates BUN elevation in these models, consistent with metabolic reprogramming as a protective mechanism

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Postmortem studies have shown higher mtDNA point mutations, large deletions, and lower mtDNA copy numbers in AD patients [149, 150]