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J Hepatol 62(5):11481155 Cobbina E, Akhlaghi F (2017) Non-alcoholic fatty liver disease (NAFLD)pathogenesis, classification, and effect on drug metabolizing enzymes and transporters

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221 Furthermore, PTBP1 hyperlactylation in GSCs promotes glioma progression and supports the maintenance of GSCs by inhibiting its interaction with TRIM21 and enhancing its RNA-binding affinity and stabilizing PFKFB4 mRNA, which in turn accelerates glycolysis, eventually forming a feedback loop that exacerbates tumorigenesis

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