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Distinct from ferroptosis, cuproptosis is driven by copper ion-induced proteotoxic stress within the mitochondrial respiratory chain

This is an in vivo, systemic treatment, administered intravenously in a single dose

Wimer, G.S., D.R

After the in vitro simulated gastrointestinal digestion, the reducing power of WPH-GI showed no significant change compared to WPH, indicating that the papain hydrolysate has good digestion stability

On the contrary, under nutrient deprivation conditions (4 h EBSS treatment), mTOR de-phosphorylates and stops inhibiting ULK, thus favoring the induction of autophagy

In addition to the erythrocyte membrane, host nutrients also need to cross the encasing parasitophorous vacuole membrane (PVM) and the parasite plasma membrane to access the parasite