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Studies suggest that a significant proportion of long-term metformin users may develop biochemical B12 deficiency, though estimates vary widely depending on the population studied, the duration of use, and the B12 threshold applied

Vitamin C in extremely high doses (more than 1000 mg taken with a b12 supplement) may reduce b12 absorption when taken together

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No, thats the short and sweet answer

6 Hemoglobin is an essential protein for oxygen transport in blood which consists of four heme groups and iron ion that reduced form or ferrous state [Fe2+]

Methotrexate may also cause inflammation in your lungs, leading to scar tissue buildup