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doi: 10.4049/jimmunol.173.5.3186 18 KunisawaJHashimotoEIshikawaIKiyonoH

Besides, Dysregulation of TGF- and IL-4 signaling may also be responsible for the pro-fibrotic function in SSc macrophages (159)

Thrombus formation and the subsequent activation of the coagulation cascade with final generation of fibrin is facilitated by the mCRP-mediated enhancement of tissue factor on the endothelial cell surface, platelet aggregation and thrombus growth (207, 208) (Figure 7)