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While the treatment is intended as a single dose treatment, Intellia offered the higher dose to these participants after it was shown to be more efficacious

D.MartinM.HouckK.BrowneP.et al (2017)

Mugisha, S

Inositol is a type of sugar found in the human body, and it helps reduce blood cholesterol and helps support the metabolic process

It does this by taking a methyl group from 5-methyltetrahydrofolate (the active form of folate), transferring it back to the cobalamin, and releasing free tetrahydrofolate

for instance, this modification may alter the secondary structure, enhancing mRNA accessibility to nucleases, or the mRNA may possess sequences that facilitate premature degradation, such as AU-rich elements