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Clinical challenges and mitigation strategies Core clinical and research challenges With the widespread clinical use of platinum-based chemotherapeutics, long-term in vivo platinum accumulation has emerged as a critical yet underrecognized clinical challenge, serving as the core toxicological driver of impaired long-term quality of life and adverse health outcomes in cancer survivors

Zohn (Center for Genetic Medicine Research, Children's National Research and Innovation) for providing the HECTD1 plasmid

M1-like macrophages predominantly utilize anabolic metabolism, specifically glycolysis and the PPP, to generate energy and synthesize cellular components, whereas M2-like macrophages are more reliant on OXPHOS, particularly through the enhancement of FAO

Hilchey, S

Structural optimization has led to the development of second- and third-generation ferrostatins, such as liproxstatin-1, SRS11-92, SRS16-86, and UAMC-3203, which exhibit enhanced stability and in vivo activity (414, 415)

110,111 It has been demonstrated that CRP levels in saliva moderately correlated with those in serum samples and with systemic inflammation, postulating this via as a useful strategy to assess various inflammatory conditions