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Hyperhomocysteinemia damages the vascular endothelium, causing oxidative stress, inflammation and endothelial dysfunction, which leads to platelet activation and coagulation cascade dysregulation, markedly increasing the risk of arterial and venous thrombosis

Xie et al., 2024)

Tumor immunology and immunotherapy of non-small-cell lung cancer

[DOI] [PMC free article] [PubMed] [Google Scholar] 82.Barichello T., Ceretta R.A., Generoso J.S., Moreira A.P., Simes L.R., Comim C.M., Quevedo J., Vilela M.C., Zuardi A.W., Crippa J.A., et al

Also, the same effect was observed in the administration of carboplatin and paclitaxel in combination with VIC on ovarian cancer cell lines

While a direct in-study comparison would provide the most stringent comparison, these data suggest no major deficits in the humoral responses of DIO mice