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Two factors are important: one, the ability to read, which in the Dark Ages and Middle Ages was rare

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ACR [cited 2023 July 21]

Nat Protoc 15(2):668693

For the purposes of this comparison, the important point is narrow and factual: tesamorelin and sermorelin are both GHRH-receptor agonists, so they share a mechanism with each other and with native GHRH, but not with the ghrelin-receptor secretagogues