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References The Lancet.

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Of the remaining 45 articles, 6 full texts could not be retrieved and 14 were excluded as they were out of scope

Browning of White Adipose Tissue Third, and perhaps most fascinating, NNMT inhibition promotes browning of white adipose tissue - the conversion of white adipocytes into beige/brown adipocytes that contain numerous mitochondria and express uncoupling protein 1 (UCP1), enabling them to dissipate energy as heat through non-shivering thermogenesis

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It supplies the mechanistic and directional rationale for the whole compound class, but it is not a human trial and does not establish a human dose