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Knockdown of each gene diminished GSH levels, and knockdown of Idh2 and Me1 also increased GSSG levels, thus elevating the GSSG/GSH ratio (Figure 6D)

in contrast, only Cu chelator treatment show potent rescue effect on such excess Cu 2+ -induced cell death, suggesting that cuproptosis is distinct from other forms of cell death

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Discussion Triple-negative (ER, PR, and HER2 negative) breast cancer, having no receptor sensitivity, is the most lethal subtype of breast cancer because of its heterogeneity, aggressiveness, and lack of treatment options

The amino acid sequence of rat liver G6PD shows 94% homology to the human sequence and provides evidence that the N-terminal amino acid is N -acetylalanine, which must result from posttranslational cleavage of the N-terminal methionine