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some strains create fewer or none, others produce more toxic metabolites [31,74]

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Moreover, it is the only candidate drug for ALS to be independently validated by the ALS Therapy Development Institute (Soon et al., 2011)

Cu 2+ functions by binding and regulating growth factors and cell membrane receptors in the extracellular environment, while Cu + exists on the cell membrane and directly regulates kinase activity to alter the activation state of growth factor membrane receptors through structural modification and inhibition of phosphatase function

EULE treatment elicited a significant upregulation of nsy-1, sek-1 , and pmk-1 mRNA expression ( p 0.05

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