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Graphical Abstract Keywords Gut microbiota, Ferroptosis, Nonalcoholic fatty liver disease, Gut-liver axis Introduction Because of its close association with metabolic diseases and the many challenges faced by previous diagnostic strategies of exclusion, a new disease nomenclature, metabolic-associated fatty liver disease (MAFLD), has been proposed to replace the previous name, nonalcoholic fatty liver disease (NAFLD)

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Because the maturation of autolysosomes and their retrograde transport are impeded in AD, a massive accumulation of defective autophagosomes can lead to autophagy intermediates (autophagic and lysosomal vesicles) within large swellings along dystrophic and degenerating neurites (Nixon, 2007)

Fecal microbiome transplantation attenuates manganese-induced neurotoxicity through regulation of the apelin signaling pathway by inhibition of autophagy in mouse brain

ACSL4 inhibitors have decreased ferroptosis in AD mice, but their poor target selectivity makes them unsuitable for human trials (Jia et al., 2023

At biological levels (10 mM), GSH had no disruptive impact on the bacterial species tested with the exception of for S